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author:admin   source:admin   published:2013-11-18 16:44:03

Product name: posaconazole

CAS: 171228-49-2

Molecular formula: C37H42F2N8O4

Molecular weight: 700.78

Description: Posaconazole is a triazole antifungal drug marketed in theUnited States, the European Union, and in other countries by Schering-Plough under the trade name Noxafil. InCanada, posaconazole is marketed by Schering-Plough under the trade name Posanol.

Posaconazole works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems such as ATPase and enzymes of the electron transport system, thus inhibiting growth of the fungi. It does this by blocking the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors. Posaconazole is significantly more potent at inhibiting 14-alpha demethylase than itraconazole.